Histidine and L-Histidine Information

Histidine is an amino acid located within the proteins of all living organisms. While the majority of histidine is found in proteins, there is a much lesser amount that also exists in some plants and fermented foods. Carnosine and anserine, both naturally occurring dipeptides found in muscles, are both comprised of histidine (L-histidine) and beta-alanine.

Histidine is considered by many in the health industry to be one of only 10 essential amino acids for infants. However, it is not clear whether or not histidine is an essential amino acid for adults. At the very least, histidine is an important amino acid for all humans. While L-histidine (a type of histidine) is produced naturally by the body, under certain circumstances (including stress and disease), enough may not be produced to meet physiological requirements.

Benefits of Histidine

L-histidine, a common form of histdine, has been used in association with rheumatoid arthritis. It has been suggested that those suffering from rheumatoid arthritis produce lower than normal levels of histidine. In a study conducted on rheumatoid arthritis sufferers, each participant was given 6 grams of supplemental histidine daily. Analysis of study results indicated that participants would benefit with as little as 1 gram daily. A similar study where patients received 4.5 grams of supplemental histidine daily found much smaller benefits, but still enough to merit additional research.

Note: No clinical trials have provided conclusive evidence as to the medicinal benefits of histidine supplementation.

Dosage and Administration

Most people do not need to supplement with histidine. Optimal levels for others remain unknown. Human research has used between 1 gram and 8 grams per day.