Pregnenolone Information

Pregnenolone is a naturally occurring steroid found in animal tissues including the adrenal gland, brain, and gonads. Pregnenolone is synthesized from cholesterol and is the precursor to a number of steroid hormones including dehydroepiandrosterone (DHEA) and progesterone.

While many effects of pregnenolone have been reported, it appears that the most powerful affect that pregnenolone offers is its ability to enhance memory. In a study of healthy men, ages 20 to 30, pregnenolone (1 mg daily) was found to improve sleep quality and decrease intermittent wakefulness.

It has also been reported that pregnenolone may play an important role in the neuroendocrine response to stress.

It has been reported that pregnenolone may also be beneficial for use in connection with a variety of rheumatologic diseases including rheumatoid arthritis. In a clinical study where 50-600 mg of pregnenolone was injected daily, six of eleven rheumatoid arthritis patients experienced a noticeable improvement in joint pain and joint mobility, which lasted for two to four days following the therapy. In a similar study of osteoarthritis patients, pregnenolone therapy was able to reduce pain and improved mobility in seven of the participants. However, pain did come back shortly after the therapy was discontinued..

Pregnenolone Dosage Recommendations

Typical pregnenolone doses are 5 to 50 milligrams daily. The safety of taking pregnenolone at any dose, especially long term, is unknown.