Cirrhosis of the Liver

Cirrhosis of the liver occurs when severe damage has been done to the liver, weakening its capability to function normally. The most common origin of liver cirrhosis in the United States is chronic alcoholism. Cirrhosis can also be caused from a chronic viral infection of the liver (hepatitis types B, C, and D) or an inherited disease, such as cystic fibrosis, hemochromatosis, and Wilson's disease.

Nutritional supplements that may be helpful for cirrhosis of the liver

S-adenosylmethionine (SAMe) taken in large doses may help with survival and liver function in alcoholic liver cirrhosis. In a double-blind trial, SAMe greatly reduced the overall death rate and need for liver transplants in people with less advanced alcoholic liver cirrhosis. The results of another preliminary trial suggests that smaller doses of SAMe may improve liver function. SAMe has reversed depletion of glutathione, an antioxidant needed for health liver function. It also helped the resolution of blocked bile flow, called cholestasis, which is a complication common among those with liver cirrhosis.

L-ornithine-L-aspartate (OA) has been researched as treatment for cirrhosis and hepatic encephalopathy. A double-blind trial showed considerable progress in liver function, mental status, and brain function when participants were treated with 18 grams of OA daily for 14 days. Progress was also seen when injections of OA were used.

Although compelling clinical research is lacking, L-carnitine injections have shown to help cirrhosis patients increase circulation to their liver.

Vitamin E can help reduce damage in cirrhotic livers and can lower the immune defects that aid in the progression of the disease.

Herbs that may be helpful for liver cirrhosis

Bupleurum, a Chinese herb, is found in the supplement complex sho-saiko-to is thought to improve liver cirrhosis. A preliminary trial showed sho-saiko-to lowered the risk of cancer in participants with liver cirrhosis when they took 2.5 grams three times each day.

Milk thistle extract high in a flavonoid compound known as silymarin, can increase liver function and survival rate in patients with cirrhosis. In clinical trials, silymarin (420 to 600mg per day) increased liver function tests and defended liver cells against oxidative damage to those with liver disease related to alcohol.