GABA (Gamma-Amino Butyric Acid) Information

GABA is a major inhibitory neurotransmitter in the central nervous system. When the level of GABA in the brain decreases below a certain level, seizures and other neurological disorders may occur. The level of GABA in the brain is controlled by two enzymes, glutamate decarboxylase (GAD) and GABA transaminase (GABA-T).

GABA is considered to act as a natural calming and anti-epileptic agent in the brain. Since GABA is not transported efficiently into the brain from the bloodstream, most of the GABA found in the brain is manufactured there. For that reason, supplemental GABA would not be expected to increase levels of GABA in the brain. Howver, a few physicians have reported that GABA can be beneficial when used in connection with a variety of brain disorders including epilepsy and schizophrenia, but these reports have not been substantiated by human pharmacological studies. Intake of high levels GABA has shown to produce a marked increase in plasma growth-hormone levels and prolactin in one study, but the implication and application of these findings is not yet clear.

Usage and Dosage

GABA can be purchased as a nutritional supplement in capsule and tablet form. Some doctors have recommended GABA in the amount of 200 mg four times daily, although no general recommendation is made for supplementation of GABA.