Calcium D-glucarate Information
Calcium D-glucarage (the calcium salt of D-glucaric acid) is a relatively common nutrient found in many fruits and vegetables. Many researchers believe that this nutrient aids the body in the elimination of many harmful substances and to lower abnormally high levels of estrogen. Both these effects may help to protect against the development of breast, colon, and prostate cancers.
Some studies have indicated that calcium D-glucarate may help to inhibit beta-glucuronidase, an enzyme found in certain bacteria that reside in the intestines. One way that toxic chemicals, as well as hormones such as estrogen, are eliminated from the body is by attaching glucuronic acid to them in the liver and then excreting them together in as substance called bile. Beta-glucuronidase is a bacterial enzyme that uncouples (breaks) the bond between the excreted compound and glucuronic acid. When beta-glucuronidase breaks the bond, the hormone or toxic chemical that is released is available to be reabsorbed into the body instead of being excreted. An elevated beta-glucuronidase activity is associated with an increased risk for various cancers, particularly hormone-dependent cancers like breast, prostate, and colon cancers.
Based on this reasoning, some healthcare professionals believe that calcium D-glucarate may in fact aid in the prevention of different deadly cancers.
Dosage
Calcium D-glucarate (as calcium salt - glucaric acid) is available in capsules and tablets. Although we know of no recommendations for dosing that are available in scientific literature, a commonly suggested dose for possible cancer prevention is 200 mg once a day or twice a day. When used in connection with existing cancers, daily doses of 1,200 mg or higher reportedly have been taken without apparent side effects. But again, more research is require to substantiate its effectiveness.